| Size | Price | Stock |
|---|---|---|
| 5mg | $155 | In-stock |
| 10mg | $280 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
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| Cat. No. : | HY-118177 |
| M.Wt: | 261.28 |
| Formula: | C16H11N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 40 mg/mL (ultrasonic) |
Neutrophil elastase inhibitor 1 is a competitive, pseudo-reversible inhibitor of human neutrophil elastase (HNE) with an IC50 of 7 nM. Neutrophil elastase inhibitor 1 also exhibits inhibitory activity against thrombin, chymotrypsin and urokinase, with IC50 values of 1.9 μM, 66 nM and 6.6 μM, respectively. Neutrophil elastase inhibitor 1 can be used in research related to acute respiratory distress syndrome, chronic obstructive pulmonary disease and other conditions[1]. IC50 & Target:IC50: 7 nM (Neutrophil elastase), 1.9 μM (Thrombin), 0.066 μM (chymotrypsin), 6.6 μM (urokinase) In Vitro:Neutrophil elastase inhibitor 1 (Compound 5b) (5 μM; 0-7 h) is a pseudo-irreversible inhibitor of human neutrophil elastase, which maintains a persistent inhibitory effect (80% of that of the control group) even 7 h after treatment with 5 μM of this compound[1].
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