(S,R,S)-AHPC
CAS No. : 1448297-52-6
(Synonyms: VH032-NH2; VHL ligand 1)
| Size | Price | Stock |
|---|---|---|
| 100mg | $13 | In-stock |
| 250mg | $20 | In-stock |
| 1g | $55 | In-stock |
| 5g | $162 | In-stock |
| 10g | $323 | In-stock |
| 25g | $666 | In-stock |
| 100g | $2132 | In-stock |
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| Cat. No. : | HY-125845 |
| M.Wt: | 430.56 |
| Formula: | C22H30N4O3S |
| Purity: | >98 % |
| Solubility: | H2O : 23.81 mg/mL (ultrasonic;adjust pH to 7 with HCl);DMSO : 100 mg/mL (ultrasonic) |
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1]. IC50 & Target:von Hippel-Lindau (VHL)[1] In Vitro:The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein[1].
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