(S,R,S)-AHPC (monohydrochloride)
CAS No. : 1448189-80-7
(Synonyms: VH032-NH2 (monohydrochloride); VHL ligand 1 (monohydrochloride))
| Size | Price | Stock |
|---|---|---|
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| 1g | $187 | In-stock |
| 5g | $529 | In-stock |
| 25g | $1878 | In-stock |
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| Cat. No. : | HY-101763A |
| M.Wt: | 467.02 |
| Formula: | C22H31ClN4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
(S,R,S)-AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1][2][3]. In Vitro:The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein[1].
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