2-D08
CAS No. : 144707-18-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $231 | In-stock |
| 50mg | $374 | In-stock |
| 100mg | $585 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114166 |
| M.Wt: | 270.24 |
| Formula: | C15H10O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM. IC50 & Target: IC50: 0.49 nM (Axl)[2] In Vitro: 2-D08 inhibits sumoylation by preventing transfer of SUMO from the UBC9-SUMO thioester to the substrate[1]. 2-D08 decreases the ratio of p-Axl to t-Axl in a dose-dependent manner. Suppression of Axl kinase activity by 2D08 disrupts the cytoskeleton and actin filaments with re-organization at cellular junctions[2].
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