Elcubragistat
CAS No. : 1446817-84-0
(Synonyms: ABX-1431)
| Size | Price | Stock |
|---|---|---|
| 5mg | $53 | In-stock |
| 10mg | $83 | In-stock |
| 25mg | $165 | In-stock |
| 50mg | $275 | In-stock |
| 100mg | $495 | In-stock |
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| Cat. No. : | HY-117632 |
| M.Wt: | 507.39 |
| Formula: | C20H22F9N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Elcubragistat (ABX-1431) is a highly effective, selective, orally active, and blood-brain barrier-permeable monoacylglycerol lipase (MAGL) inhibitor, with an IC50 value of 14 nM[1]. IC50 & Target:IC50: 14 nM (human MGLL)[1] In Vitro:Elcubragistat (ABX-1431) is a potent human MGLL inhibitor (IC50=0.014 μM) with >100-fold selectivity against ABHD6 and >200-fold selectivity against PLA2G7. Elcubragistat inhibits human PC3 cells with an IC50 of 0.0022 μM. In the cell-based assay, >100-fold selectivity for MGLL over ABHD6 (IC50=0.253 μM) and PLA2G7 (IC50=494 μM) is maintained[1]. In Vivo:Elcubragistat (ABX-1431) inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model[1].
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