RO9021
CAS No. : 1446790-62-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $430 | In-stock |
| 100mg | $580 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16902 |
| M.Wt: | 355.44 |
| Formula: | C18H25N7O |
| Purity: | >98 % |
| Solubility: | DMSO : 3.03 mg/mL (ultrasonic) |
RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of SYK, with an average IC50 of 5.6 nM. IC50 & Target: IC50: 5.6 nM (SYK) In Vitro: RO9021 is a highly selective SYK inhibitor with low S-scores of 0.003 for S(99) and 0.015 for S(90), indicating that SYK is the only kinase with 99% competition with RO9021 in a total of 392 tested kinases. RO9021 inhibits anti-IgM induced phosphorylation of BTK, PLCγ2, AKT and ERK, indicating that blockade of SYK kinase activity by RO9021 results in attenuation of BCR downstream signaling cascade. RO9021 selectively suppresses B-cell receptor signaling. RO9021 also displays a similar inhibitory potency (IC50=22.8±1.7 nM) in a FcεR-mediated mast cell activation and degranulation assay[1].
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