SR-1277
CAS No. : 1446715-47-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $970 | In-stock |
| 10mg | $1450 | In-stock |
| 25mg | $2340 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-108907 |
| M.Wt: | 477.50 |
| Formula: | C21H19N9O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1]. In Vitro: SR-1277 exhibits antiproliferative effects in A375 cells, with an EC50 of 22 nM[1]. In Vivo: SR-1277 (1 mg/kg; i.v.) exhibits Cmax (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM?h), T1/2 (1.42 h) and brain penetration (24%) in mice[1].
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