SMN-C2


CAS No. : 1446311-56-3

1446311-56-3
Price and Availability of CAS No. : 1446311-56-3
Size Price Stock
5mg $340 In-stock
10mg $540 In-stock
25mg $1090 In-stock
50mg $1350 In-stock
100mg $1780 In-stock
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Cat. No. : HY-124648
M.Wt: 417.50
Formula: C24H27N5O2
Purity: >98 %
Solubility: DMSO : 7.14 mg/mL (ultrasonic;warming;heat to 80°C)
Introduction of 1446311-56-3 :

SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research[1]. In Vivo:SMN-C2 (20 mg/kg, daily) can replace SMN2 splicing and divert FL mRNA, resulting in increased SMN protein levels in the brain and spinal cord of mice[2].

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