Fonsartan (free acid)
CAS No. : 144628-52-4
(Synonyms: HOE-720 (free acid))
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| Cat. No. : | HY-119379 |
| M.Wt: | 544.69 |
| Formula: | C26H32N4O5S2 |
| Purity: | >98 % |
| Solubility: |
Fonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID50 = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases[1].
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