CUDC-427
CAS No. : 1446182-94-0
(Synonyms: GDC-0917)
| Size | Price | Stock |
|---|---|---|
| 5mg | $118 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $340 | In-stock |
| 50mg | $545 | In-stock |
| 100mg | $900 | In-stock |
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| Cat. No. : | HY-15835 |
| M.Wt: | 564.70 |
| Formula: | C29H36N6O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers. In Vitro: GDC-0917 (0.1 nM-10 μM) induces reduction of cIAP1 levels in PBMCs in a concentration-dependent manner showing greater than 80% inhibition at concentrations greater than 0.1 µM (56.5 ng/mL)[1]. In Vivo: GDC-0917 (0.08-16.3 mg/kg) exhibits antitumor activity in a dose dependent manner in the MDA-MB-231-X1.1 Breast Cancer Xenograft, and GDC-0917 is well tolerated, with all dose groups experiencing a <11% decrease in mean body weight. GDC-0917 has low to moderate clearance in the mouse (12.0 mL/min/kg), rat (27.0 mL/min/kg), and dog (15.3 mL/min/kg), and high clearance in the monkey (67.6 mL/min/kg). Oral bioavailability is lowest in monkeys compared with other species[1].
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