Leelamine
CAS No. : 1446-61-3
| Size | Price | Stock |
|---|---|---|
| 1g | $5 | In-stock |
| 10g | $10 | In-stock |
| 25g | $20 | In-stock |
| 100g | $27 | In-stock |
| 500g | $127 | In-stock |
| 1000g | $252 | In-stock |
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| Cat. No. : | HY-W005629 |
| M.Wt: | 285.48 |
| Formula: | C20H31N |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Leelamine is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor with an IC50 value of 9.5 μM, showing a blood glucose lowering effect in the diabetic mouse. Leelamine is also a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine decreases mitotic activity, prostate-specific antigen expression and induces Apoptosis to cell death in cancer cells[1][2][3].
In Vitro:Leelamine (3 μM, 3 h) induces vacuolization of cells, accumulation of lipofuscin-like material, formation of web-like membrane whorls and inhibition of autophagic flux in melanoma cells[2].
Leelamine (3 μM, 3 h) induces intracellular cholesterol accumulation and alters cholesterol subcellular localization in UACC 903 or 1205 Lu melanoma cells[2].
Leelamine (3-5 μM, 3-12 h) inhibits signaling pathways driving melanoma cell survival and disrupts RTK signaling via interference with intracellular vesicular transport systems[2].
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