Paliperidone
CAS No. : 144598-75-4
(Synonyms: 9-Hydroxyrisperidone)
| Size | Price | Stock |
|---|---|---|
| 50mg | $72 | In-stock |
| 100mg | $110 | In-stock |
| 200mg | $165 | In-stock |
| 500mg | $330 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-A0019 |
| M.Wt: | 426.48 |
| Formula: | C23H27FN4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].
In Vitro:Paliperidone (10-100 μM, 12-24 h) increase caspase-3 activity in neuroblastoma cells[5].
Paliperidone (50-200 μM, 3 h) may modulate Akt1/GSK3β pathway to effectively protect SK-N-SH cells from the damages induced by glutamatein[6].
Paliperidone (100 μM, 24 h) can protect SK-N-SH cells from apoptosis induced by glutamate[6].
In Vivo:Paliperidone (0.1-6 mg/kg, i.p., once time) significantly increases fasting glucose levels in female Sprague-Dawley rats[7].
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