GPR84 antagonist 8
CAS No. : 1445846-30-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $700 | In-stock |
| 50mg | $1200 | In-stock |
| 100mg | $1980 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-112562 |
| M.Wt: | 421.45 |
| Formula: | C23H23N3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
GPR84 antagonist 8 is a selective GPR84 antagonist. IC50 & Target: GPR84[1] In Vitro: GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. To test the hypothesis that blocking the activation of GPR84 can be a potential anti-inflammatory strategy in different inflammatory diseases, GPR84 antagonist 8 is used. The potency and specificity of GPR84 antagonist 8 is assessed tusing GPR84-CHO cells in the cAMP assay. GPR84 antagonist 8 effectively inhibits the action of 6-OAU in decreasing cAMP production in GPR84-CHO cells. To test GPR84 antagonist 8’s inhibition of the pro-inflammatory effects of GPR84 activation in macrophages, LPS pre-treated BMDMs are incubated with 10?μM GPR84 antagonist 8 for 30?min before adding 1?μM 6-OAU. Protein analysis by Western Blot shows that the GPR84 antagonist 8 partially blocks the phosphorylation of AKT and ERK induced by 6-OAU[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- GPR84 antagonist 8
- Cat. No.:
- HY-112562
- Quantity:
Your information is safe with us.