BAY-524
CAS No. : 1445830-39-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $680 | In-stock |
| 50mg | $1950 | In-stock |
| 100mg | $2900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-104001 |
| M.Wt: | 482.48 |
| Formula: | C24H24F2N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 166.67 mg/mL (ultrasonic) |
BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents[1].
IC50 & Target:IC50: 450 nM (human Bub1)[1]
In Vitro:BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM[1].
BAY-524 (7-10 μM or 0-30 μM; 14 h or 1 h) specifically inhibit Bub1 kinase[1].
BAY-524 (7 μM , 12 h or 7 μM, 12 μM, 3 h) affects Sgo1 and Sgo2 localization and chromatid cohesion in cells[1].
BAY-524 (7 μM, 10 μM) affects localization and activity of the CPC[1].
BAY-524 (7 μM, 2 h) exerts additive effect on centromere association of CPC[1].
BAY-524 (7 μM, 48 h) marginally affects SAC signaling[1].
BAY-524 (7 μM, 10 μM) sensitizes cells to low doses of paclitaxel[1].
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