ALS-8112
CAS No. : 1445379-92-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $180 | In-stock |
| 5mg | $420 | In-stock |
| 10mg | $600 | In-stock |
| 50mg | $1800 | In-stock |
| 100mg | $2520 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12983 |
| M.Wt: | 293.68 |
| Formula: | C10H13ClFN3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 47 mg/mL |
ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM. IC50 & Target: IC50: 0.02 μM (RSV)[1] In Vitro: The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis[2]. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination[3]. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro. The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC50 of 0.020 ± 0.008 μM[4].
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