Licochalcone C
CAS No. : 144506-14-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $144 | In-stock |
| 5mg | $360 | In-stock |
| 10mg | $530 | In-stock |
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| Cat. No. : | HY-N0374 |
| M.Wt: | 338.40 |
| Formula: | C21H22O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively. IC50 & Target: IC50: <100 nM (α-glucosidase), 92.43 μM (PTP1B)[1]. In Vitro: Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively[1]. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration?dependent manner. Licochalcone C treatment reduces the levels of the anti?apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells[2].
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