SCH-42354
CAS No. : 144505-58-8
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| Cat. No. : | HY-106975 |
| M.Wt: | 341.49 |
| Formula: | C16H23NO3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the prodrug SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2]. In Vitro: SCH-42354 (10-100 nM) increases the potency of natriuretic peptide (ANP) in isolated pulmonary vessels and in isolated perfused whole lungs and increases ANP activity in a dose-dependent manner[1].
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