Binodenoson
CAS No. : 144348-08-3
(Synonyms: MRE-0470; WRC 0470)
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $450 | In-stock |
| 25mg | $750 | In-stock |
| 50mg | $1000 | In-stock |
| 100mg | $1400 | In-stock |
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| Cat. No. : | HY-106450 |
| M.Wt: | 391.42 |
| Formula: | C17H25N7O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1]. In Vitro: Binodenoson (MRE-0470) (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram[1]. In Vivo: Binodenoson (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage[1].
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