ML 297
CAS No. : 1443246-62-5
(Synonyms: VU 0456810; CID 56642816)
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $530 | In-stock |
| 200mg | $742 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-110192 |
| M.Wt: | 328.32 |
| Formula: | C17H14F2N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 can cross the blood-brain barrier with brain-to-plasma ratio of 0.2 in mice model (i.p.). ML 297 is potential for the treatment of epilepsy[1][2].
IC50 & Target:EC50: 0.16 μM (GIRK1/2), 18 μM (GIRK1/4)[1]
In Vitro:ML 297 is completely inactive for GIRK2/3[1].
ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC50 of 162 nM[2].
ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3[2].
In Vivo:ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the GABAA antagonist pentylenetetrazol (PTZ) treatment[2].
ML297 (60 mg/kg; ip) shows a maximal free plasma concentration (Cmax) of 640 nM with a corresponding free brain Cmax of 130 nM, producing a brain-to-plasma ratio of 0.2[2].
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