Fomivirsen
CAS No. : 144245-52-3
(Synonyms: ISIS-2922)
| Size | Price | Stock |
|---|---|---|
| 1mg | $125 | In-stock |
| 5mg | $312 | In-stock |
| 10mg | $548 | In-stock |
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| Cat. No. : | HY-112958 |
| M.Wt: | 6682.40 |
| Formula: | C204H263N63O114P20S20 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fomivirsen (ISIS-2922) is an antisense phosphorothioate oligonucleotide. Fomivirsen is an antiviral reagent used in research on cytomegalovirus (CMV) retinitis. Fomivirsen binds to and degrades the mRNA of CMV immediate-early 2 protein, thereby inhibiting viral proliferation. Fomivirsen can be used in research related to cytomegalovirus retinitis and cytomegalovirus diseases[1][2].
In Vitro:Fomivirsen (0.1-10 μM; overnight) potently inhibits the replication of the HCMV strain AD169 in NHDF cells, with a mean EC50 of 0.37 μM[1].
Fomivirsen (1.2-10 μM; overnight) reduces the total infectious HCMV titer by 2 log units at a concentration of 2.2 μM, and reduces the intracellular titer by >3 log units at 10 μM, in NHDF cells[1].
Fomivirsen (0.1-1 μM; overnight pre-treatment) inhibits HCMV plaque formation in NHDF cells; for the AD169 strain, its IC70 is 0.1 μM, and for the Towne strain, its EC50 is 0.3 μM[1].
Fomivirsen (0.25-8 μM; 15-24 h) reduces the protein expression of HCMV IE1 and IE2 in NHDF cells in a dose-dependent manner[1].
Fomivirsen inhibits HCMV with an EC50 of 0.1 μM[1].
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