Opiranserin
CAS No. : 1441000-45-8
(Synonyms: VVZ-149)
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| Cat. No. : | HY-109067 |
| M.Wt: | 394.51 |
| Formula: | C21H34N2O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Opiranserin (VVZ-149), a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin is development as an injectable agent for the treatment of postoperative pain[1][2][3]. In Vivo:Opiranserin (25 mg/kg, s.c.) effectively reduced mechanical allodynia and pain-related behaviors with efficacy comparable to 3 mg/kg Morphine[3]. Opiranserin (80 mg/kg, p.o.) reduced mechanical allodynia in a rat SNL model[4].
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