Sulfapyridine
CAS No. : 144-83-2
| Size | Price | Stock |
|---|---|---|
| 1g | $10 | In-stock |
| 5g | $20 | In-stock |
| 25g | $29 | In-stock |
| 100g | $49 | In-stock |
| 500g | $149 | In-stock |
| 1000g | $254 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-B0212 |
| M.Wt: | 249.29 |
| Formula: | C11H11N3O2S |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 60 mg/mL (ultrasonic) |
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities[1][2][3].
In Vitro: Sulfapyridine inhibits production of IL-8, chemokine (C-X-C motif) ligand 1 (CXCL1), and monocyte chemotactic protein-1 (MCP-1) in synovial cells of rheumatoid arthritis (RA)[1].
MIC range of Sulfapyridine for Y. enterocolitica is 3.1-25 μg/mL and for Salmonella 25-100 μg/mL. Campylobacter jejuni/coli are less susceptible to Sulfapyridine with MIC values ranging from 200 to 800 μg/mL. Shigella and three of five E. coli strains are resistant to 1600 μg/mL of sulfapyridine. Two strains of E. coli are inhibited by 25 μg/mL[2].
In Vivo: Sulfapyridine (1 and 10 μg/kg; i.p.) significantly inhibits systemic allergic reaction induced by compound 48/80 in rats[4].
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