MJN110
CAS No. : 1438416-21-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $99 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $352 | In-stock |
| 100mg | $627 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117474 |
| M.Wt: | 462.33 |
| Formula: | C22H21Cl2N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
MJN110 is an orally active and selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 9.1 nM and 2.1 nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively[1]. MJN110 produces opioid-sparing effects and displays strong antihyperalgesic activity[2]. IC50 & Target: IC50: 9.1 nM (hMAGL) and 2.1 nM (2-AG)[1] In Vitro: MJN110 (0.01-1000 nM; 4 hours) has the primary serine hydrolase target, hMAGL, with an IC50 of ~1 nM and 10- and 100-fold selectivity windows over ABHD6 and LYPLA1/2, respectively[2]. In Vivo: MJN110 (i.p.; 0.0818 mg/kg; twice daily for 5.5 days) reverses chronic constriction injury (CCI)-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. The respective ED50 value (95% confidence limits) is 0.430 (0.233-0.793) mg/kg[1].
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