Elacridar
CAS No. : 143664-11-3
(Synonyms: GF120918; GW0918; GG918; GW120918)
| Size | Price | Stock |
|---|---|---|
| 5mg | $46 | In-stock |
| 10mg | $72 | In-stock |
| 25mg | $158 | In-stock |
| 50mg | $252 | In-stock |
| 100mg | $372 | In-stock |
| 200mg | $600 | In-stock |
| 500mg | $920 | In-stock |
| 1g | $1200 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-50879 |
| M.Wt: | 563.64 |
| Formula: | C34H33N3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on drug distribution to brain and the research of cancer[1][2]. IC50 & Target: P-glycoprotein (Pgp), BCRP[1] In Vitro: Elacridar (0.001-1 μM; 2 h) inhibits cell viability of 786-O cells[2]. Elacridar (5 μM; 24 h) affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines[2]. Elacridar (5 μM; 24 h) affects 99mTc-MIBI intracellular accumulation in MCF-7 and 786-O cells[2]. In Vivo: Elacridar (100 mg/kg; i.p. once) shows different distribution in brain and plasma[1].
| Mice PO 100 mg/kg |
Mice IP 100 mg/kg |
Mice IV 2.5 mg/kg |
|
| CL/F (ml/min) | 2.05 | 33.2 | 0.46 |
| Vd/F (liter) | 3.5 | 12.3 | 0.17 |
| t1/2 (h) | 20 | 4.3 | 4.4 |
| AUC0-inf (μg?min/ml) | 1460 | 90.3 | 161.4 |
| F | 0.22 | 0.013 | 1 |
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