Benarthin
CAS No. : 143651-45-0
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| 10mg | $210 | In-stock |
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| Cat. No. : | HY-117738 |
| M.Wt: | 411.41 |
| Formula: | C17H25N5O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Benarthin is an orally active Pyroglutamyl peptidase inhibitor, THY1 inhibitor (with a Kd value of 5.13e-08 M) and competitive PGP-1 inhibitor (Ki = 1.2 µM). Benarthin is isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. Benarthin disrupts the THY1-SFRP1 interaction, inhibits the activation of the GSK3α/β-β-catenin pathway, and reduces the upregulation of FASLG. Benarthin attenuates urothelial anoikis and reduces cell Apoptosis. Benarthin possesses iron-chelating activity. Benarthin maintains urothelial barrier integrity and blocks the pathological cascade of renal interstitial fibroblasts induced by HAP stimulation. Benarthin can be used in studies related to kidney stones[1][2][3].
In Vitro:Benarthin chelates iron[1].
Benarthin (1-20 μM) inhibits FASLG in HAP-treated hRIF in a dose-dependent manner[2].
In Vivo:Benarthin (p.o.) reduces Faslg expression in renal interstitial fibroblasts and enhances urothelial retention in mouse models of Randall's Plaque[2].
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