LY5
CAS No. : 1436382-03-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $750 | In-stock |
| 10mg | $1200 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-12442 |
| M.Wt: | 329.33 |
| Formula: | C15H11N3O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LY5 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer[1]. IC50 & Target:IC50: 0.5 μM (STAT3)[1] In Vitro:LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC50 values of 0.52, 0.55 and 1.39 μM, respectively[1]. LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells[1]. LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6[1]. In Vivo:LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo[1].
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