A 419259 (trihydrochloride)
CAS No. : 1435934-25-0
(Synonyms: RK 20449 trihydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $238 | In-stock |
| 25mg | $430 | In-stock |
| 50mg | $666 | In-stock |
| 100mg | $999 | In-stock |
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| Cat. No. : | HY-15764A |
| M.Wt: | 592.00 |
| Formula: | C29H37Cl3N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
A 419259 trihydrochloride is a Src family kinases inhibitor with IC50s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn, respectively[1][2].
IC50 & Target:IC50: 9 nM (Src), <3 nM (Lck), <3 nM (Lyn), 3 μM (Abl)[1]
In Vitro:"A419259 is a second-generation pyrrolopyrimidine that blocks proliferation and induces apoptosis in CML cell lines. It induces apoptosis in K-562 cells and also inhibits Meg-01 proliferation (IC50=0.1 μM)[1].
In the absence of IL-3, A-419259 strongly inhibits DAGM/Bcr-Abl cell proliferation (IC50=0.1-0.3 μM)[1].
A-419259 also inhibits overall SFK activity in CML cell lines and blocks Src kinase activation (IC50=0.1-0.3 μM)[1].
A 419259 trihydrochloride (1 μM; 16 h) inhibits endogenous SFK (c-Src and Lck) activity, thereby inhibiting Src-driven differentiation of mES cells toward primitive ectoderm-like cells[2].
A 419259 trihydrochloride (0.3, 1 μM; 5 days) has no effect on undifferentiated colony morphology of hES cells grown in mTeSR medium[2].
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