XMD17-109
CAS No. : 1435488-37-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $46 | In-stock |
| 5mg | $98 | In-stock |
| 10mg | $180 | In-stock |
| 50mg | $460 | In-stock |
| 100mg | $695 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15665 |
| M.Wt: | 638.80 |
| Formula: | C36H46N8O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
XMD17-109 is a novel, specific ERK-5 inhibitor, with an IC50 of 162 nM. IC50 & Target: IC50: 162 nM (ERK-5)[1] In Vitro: XMD17-109 (Compound 26) inhibits ERK5 biochemically with an IC50 of 0.162 ± 0.006 μM, and blocks pidermal growth factor induced ERK5 autophosphorylation with an EC50 of 0.09 ± 0.03 μM in cells. XMD17-109 also inhibits LRRK2[G2019S] with an IC50 of 339 nM[1]. XMD17-109 demonstrats low nanomolar cellular activity judged by the significant dose-dependent reduction of mobility shifted phosphorylated ERK5 bands from sorbitol stimulated cells. XMD17-109 completely inhibits the ERK5-mediated AP1 transcriptional activity at 30 μM and has an EC50 of 4.2 μM[2].
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