Dammarenediol II
CAS No. : 14351-29-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $240 | In-stock |
| 5mg | $590 | In-stock |
| 10mg | $940 | In-stock |
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| Cat. No. : | HY-N3677 |
| M.Wt: | 444.73 |
| Formula: | C30H52O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
Dammarenediol II is a ginsenoside precursor. Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy[1][2].
In Vitro:Dammarenediol II (40 μM; 24 h) reduces O-GlcNAc levels in HepG2, Huh7, SK-HEP1, SNU-182 and SNU-387 cells[1].
Dammarenediol II (0.01-2.0 μg/mL; 30 min pretreatment, 10 min VEGF incubation) dose-dependently inhibits VEGF-induced intracellular ROS production in human umbilical vein endothelial cells, with the maximum inhibitory effect observed at 1.0 μg/mL[2].
Dammarenediol II (1 μg/mL; 30 min, 1 h VEGF) inhibits VEGF-induced stress fiber formation in human umbilical vein endothelial cells[2].
Dammarenediol II (1 μg/mL; 30 min preincubation, 90 min VEGF treatment) inhibits VEGF-induced VE-cadherin disruption and maintains the integrity of adherens junctions in human umbilical vein endothelial cells[2].
Dammarenediol II (0-50 μM; 24 h) significantly reduces the viability of HepG2 cells at 50 μM[1].
Dammarenediol II (0-40 μM; 24 h) significantly downregulates the expression level of OGT in HepG2 cells[1].
Dammarenediol II (0-40 μM; 24 h) reduces the EC50 of Etoposide (HY-13629) for regulating caspase-3/7 activity from 17.69 μM to 4.86 μM in HepG2 cells, upregulates the expression levels of cleaved-PARP1 and p53 proteins, induces apoptosis in HepG2, Huh7, SK-HEP1, SNU-182 and SNU-387 cells, and synergistically enhances the anticancer activity of Etoposide[1].
Dammarenediol II (40 μM; 24 h) inhibits the phosphorylation levels of Akt, GSK3β and mTOR in HepG2 cells[1].
In Vivo:Dammarenediol-II (2.5 μg; intravitreal; single injection) prevents retinal microvascular leakage in diabetic mice, reducing FITC-dextran fluorescence intensity to control levels[2].
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