Hydroquinidine
CAS No. : 1435-55-8
(Synonyms: Dihydroquinidine; (+)-Hydroquinidine; Hydroconquinine)
| Size | Price | Stock |
|---|---|---|
| 1g | $6 | In-stock |
| 5g | $17 | In-stock |
| 10g | $31 | In-stock |
| 25g | $66 | In-stock |
| 100g | $262 | In-stock |
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| Cat. No. : | HY-B0997 |
| M.Wt: | 326.44 |
| Formula: | C20H26N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (ultrasonic) |
Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine prolongs the QT interval and has antiarrhythmic efficacy[1][2][3][4][5].
In Vitro:Hydroquinidine (0.1 and 0.2 mM, 24 and 48 h) exhibits a remarkable anti-clonogenic and anti-tumorigenic activities activity on pancreatic cancer cells[5].
Gene expression profle of Hydroquinidine-treated cells compared to untreated controls[5]
| Gene Name | CDKN1A | CDKN1B | PUMA | BIRC5 | AKT | MKI67 | PCNA | CCNE1 |
| HCT-8 | 2.6x ↑*** | 1.7x ↑*** | 2.6x ↑*** | 1.4x ↓*** | 1.7x ↓** | 1.2x ↓** | 1.3x ↓** | 1.3x ↓*** |
| MIA PaCa-2 | 12.2x ↑*** | 2.7x ↑*** | 23.3x ↑*** | 1.09x ↔ (ns) | 1.66x ↔ (ns) | 1.02x ↔ (ns) | 1.23x ↓* | 1.04x ↔ (ns) |
| SK-HEP-1 | 3.7x ↑*** | 1.9x ↑** | 3.3x ↑*** | 3.8 ↓*** | 2.5x ↓*** | 2.6x ↓*** | 4.0x ↓*** | 1.62x ↓* |