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BR103


CAS No. : 1434873-26-3

1434873-26-3
Price and Availability of CAS No. : 1434873-26-3
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Cat. No. : HY-117992
M.Wt: 448.52
Formula: C24H28N6O3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 1434873-26-3 :

BR103 is a C3aR-specific small molecule ligand. BR103 can be used to measure ligand affinity for a G protein-coupled receptor for saturation and competitive binding[1]. IC50 & Target:C3aR[1] In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

BR103 can be used in animal modeling to create inflammatory paw edema models in Wistar rats. BR103 remains structurally intact and undegraded after in vitro exposure to rat plasma and rat liver microsomes, which are rich in cytochrome P450 enzymes. This in vitro stability of BR103 suggests potentially low in vivo clearance, high stability, and bioavailability. Paw edema induced by subplantar injection of BR103 peaks at 0.5 hours and resolves by 24 hours[2][3].

Induction of inflammatory paw edema[2][3]
Background
BR103 selectively activates Complement C3a receptor (C3aR), leading to mast cell activation and thereby inducing acute inflammatory edema and immune response[2][3].
Specific Modeling Methods
Rat: Wistar • male • 8-week-old
Administration: 350 ng • Intraplantar (i.pl.) injection • single dose
Note
350 μg BR103 is dissolved in 100 μL of 5% DMSO or isotonic saline.
Modeling Indicators
Molecular changes: Activation of mast cells, macrophages, and neutrophils, as well as myeloperoxidase (MPO); release of histamine and tryptase; increased and recruited leukocytes at the administration site; upregulation of pro-inflammatory factors (Il1β, Il6, Tnf, Ccl3, and Mcp1).
Histological changes: Localized paw edema; infiltration of macrophages and neutrophils at the inflammation site.
Correlated Product(s): λ-Carrageenan (HY-N9470)

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