LOE 908 (hydrochloride)
CAS No. : 143482-60-4
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| Cat. No. : | HY-107756 |
| M.Wt: | 749.29 |
| Formula: | C41H49ClN2O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor[1]. In Vitro:LOE 908 hydrochloride blocks cation conductance in a concentration-dependent manner with an IC50 of 560 nM, and blocks dihydropyridine-sensitive Ba2+ current through voltage-dependent Ca2+ channels with an IC50 of 28 μM in voltage-clamped A7r5 cells[1]. In Vivo:LOE 908 (4 or 2 mg/kg followed by 160 or 80 mg/kg; i.v.) hydrochloride attenuates acute neuromotor dysfunction in rats[2].
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