(rel)-MK 287
CAS No. : 143445-03-8
(Synonyms: (rel)-L-680573)
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| Cat. No. : | HY-106899A |
| M.Wt: | 510.60 |
| Formula: | C25H34O9S |
| Purity: | >98 % |
| Solubility: |
(rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis[1].
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