(Arg)9

(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC₅₀ of 0.78 μM in the glutamic acid model^[1][2]. IC50 & Target:IC50: 0.78 μM (neuroprotection)^[1] In Vitro: (Arg)9 (Nona-L-arginine; 5-10 μM) provides significant neuroprotection in a dose-response manner following glutamic acid exposure (IC₅₀=0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC₅₀=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC₅₀=6 μM)^[1]. In Vivo: (Arg)9 (Nona-L-arginine; 1 μM/kg (600 μL); i.v.; once, for 30min; male Sprague-Dawley ratspermanent middle cerebral artery stroke model) shows neuroprotective effects and reduces infarct volume^[2].