Bryostatin 3
CAS No. : 143370-84-7
| Size | Price | Stock |
|---|---|---|
| 10μg | $641 | Get quote |
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| Cat. No. : | HY-108602 |
| M.Wt: | 888.99 |
| Formula: | C46H64O17 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion[1][2].
IC50 & Target: Ki: 2.75 nM (protein kinase C)[1]
In Vitro: Bryostatin 3 (1 μM; 24 h) does not inhibit [3Hlthymidine incorporation and largely blocks the growth-inhibitory action of TPA[2].
Bryostatin 3 (1 μM; 24 h) blocks the action of TPA to inhibit cell proliferation but does not block TPA-enhanced cell-substratum adhesion[2].
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