Ac-YVAD-CHO
CAS No. : 143313-51-3
(Synonyms: L-709049)
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| 5mg | $350 | In-stock |
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| Cat. No. : | HY-120019 |
| M.Wt: | 492.52 |
| Formula: | C23H32N4O8 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL |
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1][2][3].
IC50 & Target:Ki: 3.0 (mouse ICE); Ki: 0.76 (human ICE)[1]
In Vitro: Ac-YVAD-CHO inhibits mouse and human IL-1β with IC50 values of 2.5 and 0.7 μM respectively[1].
Ac-YVAD-CHO (0.01-100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS[1].
Ac-YVAD-CHO (15.6 μM) reduces NO-induced thymocyte apoptosis[3].
Ac-YVAD-CHO (15.6 μM, 12 h) inhibits NO-induced PARP cleavage in SNAP-treated thymocytes[3].
In Vivo: Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels in blood of P. acnes-sensitized mice[1].
Ac-YVAD-CHO (2-8 μg, intrastriatal infusion) attenuates Quinolinic acid (QA)-induced apoptosis in rat striatum[2].
Ac-YVAD-CHO (10 and 50 mg/kg; i.p.; 1 hour) is cleared from the blood rapidly, and drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection[1].
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