ML334
CAS No. : 1432500-66-7
(Synonyms: LH601A)
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $800 | In-stock |
| 100mg | $1280 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-110258 |
| M.Wt: | 446.50 |
| Formula: | C26H26N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 44.65 mg/mL (ultrasonic);Ethanol : 44.65 mg/mL (ultrasonic) |
ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].
IC50 & Target: Ki: 1 μM (Keap1)[2]
In Vitro: ML334 (LH601A; 50-100 µM; 6-16 hours; HEK293 cells) treatment increases NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. And also enhances HO-1 mRNA expression between 4- and 7-fold at 6 h, with lesser fold-changes at 16 h[1].
ML334 (LH601A; 50-100 µM; 16 hours; HEK293 cells) treatment induces HO-1 and TRX1 proteins in HEK293 cells[1].
ML334 (LH601A) stimulates NRF2 expression and nuclear translocation in HEK293 cells[1].
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