VU0453595
CAS No. : 1432436-13-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $390 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $900 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-120023 |
| M.Wt: | 322.34 |
| Formula: | C18H15FN4O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
VU0453595 is a highly selective, systemically active M1 positive allosteric modulator (PAM, EC50=2140 nM) for the research of schizophrenia[1][2].
In Vitro: Application of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs)[3].
In Vivo: VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD)[1].
VU0453595 (1-10 mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration[1].
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