UWA-101 (hydrochloride)
CAS No. : 1431520-52-3
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| Cat. No. : | HY-117512 |
| M.Wt: | 255.74 |
| Formula: | C13H18ClNO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease[1][2]. In Vivo:UWA-101 hydrochloride (3 mg/kg; i.p.; single) reduces L-DOPA-induced dyskinesia in Parkinson's disease rat model[1].
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