SIRT-IN-2
CAS No. : 1431411-66-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $290 | In-stock |
| 10mg | $465 | In-stock |
| 25mg | $790 | In-stock |
| 50mg | $1080 | In-stock |
| 100mg | $1480 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16616 |
| M.Wt: | 383.49 |
| Formula: | C15H21N5O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 nM, respectively. IC50 & Target:IC50: 4 nM (SIRT1), 1 nM (SIRT2), 7 nM (SIRT3)[1]. In Vitro:SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].
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