SIRT-IN-1
CAS No. : 1431411-60-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1450 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16615 |
| M.Wt: | 389.52 |
| Formula: | C19H27N5O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 19.23 mg/mL (ultrasonic;warming;heat to 60°C) |
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 nM, respectively. IC50 & Target:IC50: 15 nM (SIRT1), 10 nM (SIRT2), 33 nM (SIRT3)[1]. In Vitro:SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].
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