Phytic acid (sodium salt)

Phytic acid (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) sodium salt is an orally active compound. Phytic acid sodium salt can be derived from the seeds of legumes. Phytic acid sodium salt is a [PO4]³- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research^{[1][2][3][4][5][6][7][8][9][10]}. IC50 & Target:IC50: precursor for inositol phosphates and pyrophosphates^[1] In Vitro:Phytic acid (0.05%-0.4% (wt/wt), 5 min) sodium salt and sodium chloride show marked synergistic bactericidal effects against nonadapted and acid-adapted Escherichia coli O157:H7 strains^[2].
Phytic acid (1-5 mM, 2-3 h) sodium salt decreases the integrity of Caco-2 cell monolayers by modulating the TJ proteins' localization and down-regulating the expression levels of TJ proteins, and does not cause cytotoxicity to Caco-2 cells^[3].
Phytic acid (48-72 h) sodium salt provides complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein in MC65 cells^[5].
Phytic acid (≥1 mM) sodium salt stimulates suicidal human erythrocyte death^[6].
In Vivo:Phytic acid (2%, diet, ad libitum for 21 d) sodium salt reduces growth performance of pigs partly through reduced capacity of the small intestine to absorb Na^[4].
Phytic acid (2%, drinking water, 6 months) sodium salt improves Alzheimer's pathology (AP180, beclin-1, LC3B, sirtuin 1) in Tg2576 mice^[5].
Phytic acid (20 mg/kg, i.p., pretreatment at 5 h before coronary artery occlusion) sodium salt suppresses ischemia-induced hydroxyl radical generation in rat myocardium^[7].
Phytic acid (100 mg/kg/d, gavage, five days a week, 8 weeks) sodium salt shows protective effects against CCl₄-induced liver fibrosis in mice^[8].
Phytic acid (4% of rodent chow, diet, 30 days) sodium salt reduces lipogenic enzyme activities in diabetic rats^[9].
Phytic acid (1-2 g/100 g, in water, 13 weeks) sodium salt shows anticarcinogenic effect in colon carcinoma rats, with 36% (1 g/100 g Phytic acid) and 42% (2 g/100 g Phytic acid) reduction in ACF, respectively^[10].