BMS-962212
CAS No. : 1430114-34-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $580 | In-stock |
| 5mg | $1450 | In-stock |
| 10mg | $2350 | In-stock |
| 25mg | $4340 | In-stock |
| 50mg | $6500 | In-stock |
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| Cat. No. : | HY-117290 |
| M.Wt: | 659.07 |
| Formula: | C32H28ClFN8O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
BMS-962212 is a factor XIa (FXIa) inhibitor with a Ki of 0.7 nM against human FXIa and a Ki of 3 nM against rabbit FXIa. BMS-962212 blocks thrombosis while preserving normal hemostatic function. BMS-962212 is applicable to thrombosis-related research[1].
In Vitro:BMS-962212 (Compound 55) at a concentration of 0.3 μM prolongs the activated partial thromboplastin time in human plasma by 1.5-fold, indicating that it possesses in vitro anticoagulant activity[1].
BMS-962212 exhibits high selectivity for FXIa and inhibits rabbit activated plasma kallikrein with a Ki of 1100 nM[1].
In Vivo:BMS-962212 (single bolus 0.23-0.46 mg/kg; continuous infusion 1.55-3.1 mg/kg/h; i.v.) inhibits arteriovenous shunt thrombosis in rabbits by up to 83% at the dose of 0.23 mg/kg single bolus combined with 1.55 mg/kg/h continuous infusion[1].
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