Lauric acid
CAS No. : 143-07-7
| Size | Price | Stock |
|---|---|---|
| 500g | $40 | In-stock |
| 1000g | $54 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-Y0366 |
| M.Wt: | 200.32 |
| Formula: | C12H24O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);0.1 M NaOH : 10 mg/mL (ultrasonic;warming;adjust pH to 11 with NaOH;heat to 60°C) |
Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively[1].
IC50 & Target:EC50: 2 μg/mL (P. acnes), 6 μg/mL (S.aureus), 6 μg/mL (S. epidermidis)[1].
In Vitro:Lauric acid (0.06-125 μg/ml, 24-72 h) has much stronger antimicrobial activity in P. acnes, S.aureus, and S. epidermidis[1].
Lauric acid (5-50 μM, 24 h) increases glucose uptake and decreases GLUT-1 expression and cellular H2O2 production in insulin-resistant macrophages[2].
Lauric acid (5-50 μM, 24 h) enhances mitochondrial content and mitochondrial biogenesis in the insulin-resistant macrophages[2].
Lauric acid (5-50 μM, 24 h) promotes the gene expressions (PPAR-γ, TFAM and PGC-1α) in THP-1 macrophages[2].
In Vivo:Lauric acid (0.1 μg/μL, i.h., once time) can effectively relieve P. acnes-induced inflammation without detrimental effects on skin cells in mice injected with P. acnes[1].
Lauric acid (1-10 mg/kg, i.v., once time) reduces blood pressure and heart rate in WKY and SHR rats[3].
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