7rh

7rh (DDR1-IN-2) is a potent inhibitor of discoidin domain receptor 1 (DDR1), with an IC₅₀ of 13.1 nM, and also less potently inhibits DDR2, with an IC₅₀ of 203 nM. 7rh is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IC50 & Target: IC50: 13.1 nM (DDR1), 203 nM (DDR2), 414 nM (Bcr-Abl), 2500 nM (c-Kit)^[1] In Vitro: 7rh (compound 1) is a potent inhibitor of DDR1, with an IC₅₀ of 13.1 nM, and less potently inhibits DDR2, with an IC₅₀ of 203 nM. 7rh also shows inhibitory activities against Bcr-Abl and c-Kit, with IC₅₀s of 414 and 2500 nM, respectively^[1].