Soticlestat
CAS No. : 1429505-03-2
(Synonyms: TAK-935; OV935)
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $290 | In-stock |
| 25mg | $580 | In-stock |
| 50mg | $870 | In-stock |
| 100mg | $1300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-109123 |
| M.Wt: | 373.45 |
| Formula: | C23H23N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2]. In Vitro: Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50 of 4.5 nM[1]. In Vivo: Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus[1].
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