AM-8735
CAS No. : 1429386-01-5
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| Cat. No. : | HY-12734 |
| M.Wt: | 568.51 |
| Formula: | C27H31Cl2NO6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AM-8735 is a potent and selective MDM2 inhibitor with an IC50 of 25 nM. IC50 & Target: IC50: 25 nM (MDM2)[1] In Vitro: AM-8735 displays substantial growth inhibition of wild-type p53 cells (IC50=63 nM) and no growth inhibition of p53-deficient cells (IC50>25 μM). AM-8735exhibits a dose-dependent increase of p21 mRNA, a direct transcriptional readout of p53 activity, in HCT116 p53wt cells (IC50=160 nM)[1]. In Vivo: AM-8735 also demonstrates significant time and concentration dependent p21 mRNA induction in vivo in a pharmacodynamic assay in SJSA-1 osteosarcoma tumors. AM-8735 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with an ED50 of 41 mg/kg[1].
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