TA-316


CAS No. : 1429321-13-0

(Synonyms: Megakaryocytes/platelets inducing agent)

1429321-13-0
Price and Availability of CAS No. : 1429321-13-0
Size Price Stock
5mg $690 In-stock
10mg $1105 In-stock
25mg $2210 In-stock
50mg $3320 In-stock
100mg $4980 In-stock
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Cat. No. : HY-112486
M.Wt: 641.56
Formula: C28H25BrN4O5S2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 1429321-13-0 :

TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells[1][2]. In Vitro:TA-316 (0.01-1000 nM; 4 days) stimulates UT-7/TPO and Ba/F3-HuMpl cells proliferation, with the EC50 values of 0.3 and 0.65 nM, respectively[2].
TA-316 (800 nM; 10 days) promotes biased megakaryopoiesis and upregulated MK lineage markers[2].
TA-316 (200 nM; 4 days) preferentially enhances VEGFA and FGF2 expression[2].

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