Retro-2 cycl
CAS No. : 1429192-00-6
(Synonyms: RN 1-001)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $260 | In-stock |
| 100mg | $420 | In-stock |
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| Cat. No. : | HY-114698 |
| M.Wt: | 320.41 |
| Formula: | C19H16N2OS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
Retro-2 cycl (RN 1-001) is a retrograde transport inhibitor with antiviral activity. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudoviruses, with an IC50 of 54 μM and 160 μM respectively[1][2][3].
In Vitro:Retro-2 cycl inhibits cellular infection by interfering with the formation of intracellular vacuoles in viruses, bacteria, or parasites[2].
Retro-2 cycl can effectively inhibit EV71 virus infection at a concentration of 12.56 μM in the cytopathic effect inhibition experiment, but when its concentration exceeds 500 μM, it shows lower cytotoxicity[3].
Retro-2 cycl (7.81-500 μM, 48h) demonstrates a dose-dependent effect on EV71-induced cytopathic effect in 293S cells, with a maximum suppression rate of 61.32±6.55%, an EC50 value of 12.56 μM, and antiviral activity represents by a selective index (SI) value greater than 39.81[3].
In Vivo:Retro-2 cycl (2-50 mg/kg, once daily for 7 days) can significantly protect 90% of newborn mice from lethal EV71 challenge[3].
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