IDH889
CAS No. : 1429179-07-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $500 | In-stock |
| 25mg | $850 | In-stock |
| 50mg | $1200 | In-stock |
| 100mg | $1800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112289 |
| M.Wt: | 436.48 |
| Formula: | C23H25FN6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1]. IC50 & Target: IC50: 0.02 μM (IDH1R132H), 0.072 μM (IDH1R132C), 1.38 μM (IDH1wt)[1]
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- IDH889
- Cat. No.:
- HY-112289
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